Fenofibrate-loaded electrospun microfibrous sheets were prepared in an attempt to enhance\nthe dissolution of the poorly soluble antihyperlipidemic agent and to improve its bioavailability.\nPhysicochemical changes that appeared during the electrospinning process were monitored using\na wide array of solid-state characterization techniques, including attenuated total reflectance\nFourier-transformed infrared spectroscopy and positron annihilation lifetime spectroscopy, while fiber\nmorphology was monitored via scanning electron microscopy. Dissolution studies carried out both\nin 0.025 M sodium dodecyl sulfate and in water revealed an immediate release of the active agent,\nwith an approximately 40-fold release rate enhancement in water when compared to the micronized\nactive agent. The dramatic increase in dissolution was attributed partially to the amorphous form of\nthe originally crystalline active agent and the rapid disintegration of the electrospun microfibrous\nsheet due to its high surface area and porosity. The obtained results could pave the way for a\nformulation of the frequently used antihyperlipidemic agent with increased bioavailability.
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